Breaking tolerance is a notorious technique used by cannabis users and medical patients to refresh their experience. However, a different medical cannabis variety can be a better option for increasing THC potency than a break in tolerance.
It’s possible that the THC dosage is now absurd. Otherwise, whatever the dose, the impact may eventually just grow stale. Or, to put it more simply, a reset is necessary. No matter the cause of THC’s decline in medical efficacy, a tolerance break may be beneficial. Alternately, altering the cannabinoid composition of the cannabis can help restore THC’s medicinal effectiveness.
Why give up when you have a new strain?
The endocannabinoid system is shielded by other cannabinoids and terpenes found in cannabis. Complete abstinence can be avoided by making use of the entire cannabimimetic repertoire. Nine clinical experiments that have been docketed together for one evaluation have found that medical cannabis can aid with withdrawal symptoms from, well, cannabis. The review was supported by the German University of Duisburg-Essen. (1)
Naboximols, an oral spray with a one-to-one ratio of CBD and THC, was the subject of some clinical trials accepted for the review that examined its effectiveness. Dronabinol, a synthetic version of THC, only relieved certain withdrawal symptoms. But CBD is a cannabinoid that has greater positive effects. The addition of CBD can at least make breaking tolerance simpler without requiring abstinence from regular intake.
The fatty acid and endocannabinoid known as anandamide are protected by compounds like CBD, which inhibit the enzyme known as Fatty Acid Amide Hydrolase (FAAH). The increase in anandamide caused by an FAAH inhibitor can maintain a consistent endocannabinoid tone because it acts as a biased and partial agonist of CB1 receptors. In any case, anandamide controls cell signaling (via ERK 1 and 2) and may prevent THC-induced CB1 receptor desensitization.
medical marijuana that controls the ECS and THC
The German review focused on cannabis use disorder therapy (CUD). CUD can be explained as a type of cannabis seeking, as was previously said. Interim internalization and desensitization of the CB1 receptor are signs of high THC use. As opposed to CB2 receptors, which briefly change to fit microbial cells. However, the motivation that drives someone to desire cannabis is rooted deeper in the biology of mammals. The EC system is a matrix made up of receptors and ligands known as the endocannabidiome. One person is more drawn to cannabis than another due to this inherently dynamic matrix.
To keep this system functioning, daily rituals like nutrition and exercise must be kept at natural levels. Alternately, genetic problems can deteriorate the system over time and result in diseases. However, excessive THC use deactivates the mechanism. As a result, prolonged high use of uncontrolled THC might deplete the ECS and cause tolerance. However, it is only short-lived because the system’s receptors regenerate after THC leaves the body after four days, or up to one month for regular users.
